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Which one of many following enzymes carries out the preliminary step in the digestion of milk in humans? This coughing would have been due to impotence research discount kamagra online amex improper movement of: (1) neck (2) epiglottis (3) tongue (4) diaphragm Ans: (2) ht tel tp eg s: ra //t m bph causes erectile dysfunction 100mg kamagra. What will occur if the secretion of parietal cells of gastric glands is blocked with an inhibitor? If for some purpose our goblet cells are non practical erectile dysfunction 60 year old man order kamagra 100mg visa, this will adversely have an effect on: (1) maturation of sperms (2) production of somatostatin (3) clean movement of food down the intes-tine (4) secretion of sebum from the sebaceous glands Ans: (3) (1) Starch and cellulose (2) Starch and fats (3) Protein and starch (4) Fat and cellulose Ans: (4) [2011] Q1245. Which one of many following statements is true relating to digestion and absorption of food in humans? Which one of many following pairs of food parts in humans reaches the stomach completely undigested? Anxiety and consuming spicy food together in an in any other case regular human, could result in [2012] Q1249. Which enzymes are more likely to act on the baked potatoes eaten by a man, starting from the mouth and because it strikes down the alimentary canal? A wholesome person eats the next food regimen - 5 gm uncooked sugar, 4 gm albumin, 10 gm pure buffalo ghee adultrated with 2 gm vegetable ghee (hydrogenated vegetable oil) and 5 gm lignin. Air is breathed via (1) Nostrils - pharynx - larynx - trachea - bronchi - bronchioles - alveoli (2) Trachea - lungs - larynx - pharynx - alveoli (3) Nose - mouth - lungs (4) Nose - larynx - pharynx - bronchus - alveoli - bronchioles Ans: (1) [1995] Q1260. Oxygen dissociation curve of haemoglobin is (1) Linear (2) Sigmoid (3) Hypobolic (4) Hyperbolic Ans: (2) [1995, 2006] Q1261. Which one of many following organs in the human body is most affected due to scarcity of oxygen? The change of gases in the alveoli of the lungs takes place by (1) active transport (2) easy diffusion (3) passive transport (4) osmosis Ans: (2) [1998] Q1264. In alveoli of the lungs, the air on the website of gasoline change, is separated from the blood by (1) alveolar epithelium, capillary endothelium and tunica adventitia (2) alveolar epithelium only (3) alveolar epithelium, capillary endothelium, a thin layer of tunica media and tunica adventitia (4) alveolar epithelium and capillary endothelium ht tel tp eg s: ra //t m. The amount 1500 ml in the respiratory volumes of a traditional human adult refers to (1) expiratory reserve volume (2) most air that may be breathed in and breathed out (3) whole lung capability (4) residual volume Ans: (4) Q1266. Intercostal muscle tissue occur in (1) ribs (2) abdomen (3) diaphragm (4) thigh Ans: (1) [2004] Q1268. Blood evaluation of a affected person reveals an unusually excessive amount of carboxyhaemoglobin content material. The affected person has been inhaling polluted air containing unusually excessive content material of (1) carbon dioxide (2) carbon disulphide (3) carbon monoxide (4) chloroform Ans: (3) [1988] Q1270. Which one of many following is a risk for most of us in regard to breathing, by making a conscious effort? Ans: (4) (1) (i) and (iv) (2) (ii) and (iii) (3) (i) and (ii) (4) (iii) and (iv) Ans: (2) (1) (iv) 3500 mL, (i) 1200mL (2) (ii) 2500mL, (iii) 4500mL (3) (i) 4500 mL, (ii) 3500mL (4) (iii) 1200mL, (iv) 2500mL Ans: (1) (1) Rh­ man and Rh­ girl (2) Rh+ man and Rh+ girl (3) Rh­ man and Rh+ girl (4) Rh+ man and Rh­ girl Ans: (4) Q1276. Listed beneath are four respiratory capacities (i­iv) and 4 jumbled respiratory volumes of a traditional human adult: Respiratory Respiratory capacities volumes (i) Residual volume 2500mL (ii) Vital capability 3500mL (iii) Inspiratory reserve 1200mL volume (iv) Inspiratory capability 4500mL Which one of many following is the right matching of two capacities and volumes? Which two of the next changes (a­d) usually are inclined to occur in the plain dwellers once they transfer to excessive altitudes (3,500 m or more)? Which one of many following is among the paths adopted by air/O2 during respiration in an adult male Periplaneta americana because it enters the animal body? Tricuspid valve is present in between (1) left ventricle and left auricle (2) sinus venosus and proper auricle (3) ventricle and aorta (4) proper auricle and proper ventricle Ans: (4) jo in [1988] Q1282. Haemophilia is (1) both a and b (2) royal disease (3) mosquito having haemocoel (4) defective blood clotting Ans: (1) ht tel tp eg s: ra //t m. Sickle cell anaemia is characterised by (1) Mental retardation (2) Leukemia (3) Hemolytic anaemia (4) Polycythemia Ans: (3) [1989] Q1285. Splenic artery arises from (1) posterior mesenteric artery (2) anterior mesenteric artery (3) intestinal artery (4) coeliac artery Ans: (4) [1989] Q1287. A vein possesses a big lumen as a result of (1) tunica interna, tunica media and tunica externa are skinny (2) tunica media and tunica externa form a single coat (3) tunica media is a thin coat (4) tunica interna and tunica media form a single coat Ans: (3) [1989] Q1288. Arteries carry oxygenated blood except (1) Hepatic (2) Pulmonary (3) Systemic (4) Cardiac Ans: (2) [1989] Q1289. Removal of calcium from freshly collected blood would (1) cause immediate clotting (2) cause delayed clotting (3) stop destruction of haemoglobin (4) stop clotting Ans: (4) [1990] Q1290. Wall of blood capillary is formed of (1) endothelial cells (2) haemocytes (3) oxyntic cells (4) parietal cells Ans: (1) jo in [1993] Q1296. Closed circulatory system happens in (1) mosquito (2) cockroach (3) housefly (4) tadpole/fish Ans: (4) [1993] Q1298.

Diseases

• Overgrowth radial ray defect arthrogryposis
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• Infective endocarditis
• Syndactyly type 1 microcephaly mental retardation
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• Congenital hemidysplasia with ichtyosiform erythroderma and limbs defects
• Trigonocephaly ptosis coloboma
• Peripheral type neurofibromatosis
• Hemorrhoid

Aminoglycosides Aminoglycoside antibiotics include amino sugars linked to impotence 1 discount kamagra line an aminocyclitol ring by glycosidic bonds what is an erectile dysfunction pump generic kamagra 100 mg with mastercard. Examples* Amikacin erectile dysfunction doctor in phoenix buy cheap kamagra 100mg, gentamicin, isepamicin, kanamycin, neomycin, netilmicin, paramomycin, streptomycin, and trospectomycin. The first of these compounds to be found was streptomycin which was isolated from the actinomycete Streptomyces griseus, in 1943 by Schatz, Bugie, and Waksman. This was soon adopted by the isolation of different members of the group in fast succession. Kanamycin and streptomycin have a extra restricted spectrum compared to the opposite aminoglycosides. In conjunction with penicillin or vancomycin, a few of these brokers (streptomycin, gentamicin), are also active in opposition to strains of Enterococci and Streptococci. Binding to plasma albumin is negligible (except in the case of streptomycin), and the obvious volume of distribution is 25% of physique weight. In the presence of renal impairment, these drugs should be used with nice warning owing to the danger of accumulation and resultant toxicity. In toxic doses, these drugs produce renal damage by binding to phospholipids on brush border membranes in the proximal renal tubules resulting in cellular dysfunction. Risk factors embody genetic predisposition, advanced age, renal illness, feminine intercourse, earlier aminoglycoside remedy, liver dysfunction, massive doses, lengthy duration of remedy, frequent doses, concomitant administration of different nephrotoxic drugs and presence of shock. Ototoxicity of aminoglycosides is expounded to high cochlear and vestibular trough concentrations resulting in damage to sensory hair cells. Rare situations of neuromuscular blockade produced by aminoglycosides is due to inhibition of acetylcholine release from presynaptic nerve terminals, as well as blockade of acetylcholine receptors. Administration of any of the aminoglycosides can cause each vestibular and auditory dysfunction which can be irreversible, owing to destruction of vestibular and cochlear sensory cells. Symptoms embody tinnitus (high pitched and continuous), deafness, and dysequilibrium characterised by ataxic gait, stumbling, and loss of steadiness on turning. With neomycin, ototoxicity is characterised by a latency of two to 6 weeks after onset of remedy, listening to loss typically being observed days to weeks after the drug has been discontinued. Streptomycin is predominantly vestibulotoxic; kanamycin, neomycin, and amikacin are predominantly cochleotoxic; gentamicin and tobramycin are each vestibulo- and cochleotoxic. Ototoxicity (deafness and vertigo) has been reported following use of topical neomycin and otic solutions containing gentamicin. About 8 to 26 % of patients receiving any aminoglycoside for a number of days develop nephrotoxicity, which is fortunately usually reversible. The following rank order of decreasing toxicity is mostly accepted for aminoglycosides: neomycin > gentamicin > tobramycin > amikacin > netilmicin > streptomycin. All aminoglycosides are capable (rarely) of causing neuromuscular blockade with consequent paralysis. The order of decreasing efficiency for blockade is neomycin > kanamycin > amikacin > gentamicin > tobramycin. Risk factors for inducing neuromuscular blockade embody concurrent use of curare-like drugs, succinylcholine, and magnesium, as well as presence of botulinum toxin and illness entities similar to myasthenia gravis. Optic nerve toxicity has been reported with streptomycin, as also peripheral neuritis and paraesthesia. Less frequent adverse effects associated with chronic aminoglycoside use embody electrolyte abnormalities, allergic reactions, hepatotoxicity, anaemia, granulocytopenia, thrombocytopenia, eosinophilia, reproductive dysfunction and toxic psychosis. Acute ischaemic retinopathy has occurred from intraocular administration of gentamicin. Hypersensitivity reactions have been reported most frequently with neomycin, including skin rashes, eosinophilia, fever, blood dyscrasias, angioedema, exfoliative dermatitis, stomatitis and anaphylaxis. Ototoxicity can be detected in the early phases by full-tone audiometric testing which is able to revealing highfrequency listening to loss. Vestibular dysfunction can be identified at its inception by electronystagmography. Gentamicin: Toxicity (primarily nephrotoxicity) could happen with persistent peak serum ranges greater than 12 mcg/ml, and/or trough ranges greater than 2 mcg/ml. Amikacin: Toxicity (primarily nephrotoxicity) could happen with persistent peak serum ranges greater than 20 to 35 mcg/ml, and trough ranges greater than 8 mcg/ml.

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This process happens earlier and rapid in some tissues rich in hydrolytic enzymes such as pancreas and gastric mucosa; intermediate in tissues like coronary heart erectile dysfunction doctors in san fernando valley discount 100 mg kamagra with amex, liver and kidneys and delayed in fibrous tissue like uterus or skeletal muscle erectile dysfunction treatment chinese medicine cheap 50mg kamagra with visa. Refrigeration of a physique quickly after death will retards the enzymatic self-digestion of cells whereas enhance in temperature promotes degradation as seen in deaths preceded by fever erectile dysfunction young men proven kamagra 100mg, exertion or death in excessive ambient temperature. In pores and skin slippage, the discharge of hydrolytic enzymes releasing at dermo-epidermal junction causes loosening of dermis from the underlying dermis in consequence, the dermis is well peel-off the dermis. Microscopically, autolysis is identified by homogenous and eosinophilic cytoplasm with loss of cellular particulars with cell remains as particles. Similarly the intima of huge blood vessels appears stained by postmortem hemolysis. Gastromalacia is postmortem rupture of gastric wall as a result of the process of autolysis. Similarly oesophagomalacia is postmortem rupture of lower end of oesophagus as a result of autolysis and lacks very important reaction. As the process of putrefaction progresses, different gases are produced such as ­ hydrogen sulphide, carbon dioxide, mercaptans, methane, ammonia, and so on. The rapid production and accumulation · · · of gases causes both bodily and chemical changes within the decomposing physique as mentioned in Table 7. The bodily changes consist of bloating the features with distension of abdomen by distending gases. In males, the fuel is forced from the peritoneal cavity down the inguinal canal into the scrotum inflicting scrotal swelling. This pigment initially outlines the superficial blood vessels and as decomposition progresses, a generalized inexperienced hue could also be imparted to physique. Putrefaction happens at different rate in numerous physique tissues and depends up on their moisture content material. Decomposition Changes External Signs Putrefaction is essentially the most absolute signal of death. Since the caecum is close proximity with stomach wall, the proper lower abdomen stains first. Similarly, the floor of liver in touch with caecum additionally exhibits greenish discolouration. In summer, the colour normally develops at about 12 to 18 hours and in winter it takes about 18-24 hours. The features puff up as a result of liberating gases and turn into unrecognizable; the entire physique turns into bloated and the tissues sodden with fluid and finally liquefy and disintegrate. The formation of sulphmethemoglobin causes greenish-brown staining of the internal walls of the blood vessels. Liquefaction of tissues Colour changes ­ color changes is due to hemolysis of red blood cells. The liberated hemoglobin is transformed into sulpmethemoglobin by hydrogen sulfide fuel and imparts greenish discolouration. Liberation of gases ­ during the means of decomposition, the proteins and carbohydrates are break up into simpler compounds. The offensive odour emitting from the useless physique is due to formation of hydrogen sulfide fuel and mercaptans. The gases are collected within the gut inside 12 to 18 hours in summer and 18 to 24 hours in winter. As the decomposition process progresses, the peculiar odour emitted by physique attracts flying insects, particularly flies (vide infra). After invasion of the our bodies by flies, they lay eggs in 18 to 36 hours depending on environmental conditions (Figs 7. Moreover, maggot secrets proteolytic enzymes that causes extra destruction and will cause issue in interpreting the floor damage. Quantity of blood in organ Therefore, the order of tissue decomposition in internal organ is as follows: 1.